NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
Ramchandra Vijay Amnekar, Toby A. Dite, Paweł Lis, Sebastian Bell, Fiona Brown, Clare Johnson, Stuart G. Wilkinson, Samantha L. Raggett, Mark Dorward, Mel Wightman, Thomas Macartney, Renata Filipe Soares, Frédéric Lamoliatte, Dario R. Alessi
This study identifies NRBP1 as an upstream activator of the WNK pathway by forming a multi-subunit complex with WNK1, SPAK, and TSC22D4 in response to osmotic stress.
Science Advances · Jul 16, 2025Peer-reviewedCell Biology