Cancer BiologybioRxivPreprint
Overcoming resistance to KRAS inhibition in KRAS/PIK3CA co-mutated colorectal cancer
Lucille Ferret, José L Montaño, Kasturi B Nayak…·John D Gordan
This study shows that PI3K mutations contribute to resistance to KRAS inhibitors in colorectal cancer and that combining RAS and PI3K inhibition overcomes this resistance.
DOI 10.64898/2026.11.10.765758