BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes
Changyi Ji, Maoping Tang, Claudia Zeidler, Jörg Höhfeld, Gail V.W. Johnson
This study shows BAG3 and SYNPO promote autophagy-mediated degradation of phosphorylated MAPT in neuronal synapses, preventing its accumulation and maintaining synaptic health.
Autophagy · Feb 12, 2019Peer-reviewedNeuroscience