BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance
Heng Lin, Maoping Tang, Changyi Ji, Peter Girardi, Gregor Cvetojevic, Daniel Chen, Shon A. Koren, Gail V.W. Johnson
This study identifies a BAG3-TBC1D10B-Rab35 regulatory axis that modulates ESCRT-dependent tau clearance and links its dysfunction to Alzheimer's disease pathogenesis.
Biological Psychiatry · Nov 10, 2021Peer-reviewedNeuroscience