Direct and indirect regulation of β- glucocerebrosidase by the transcription factors USF2 and ONECUT2
Kathi Ging, Lukas D. Frick, Johannes C. M. Schlachetzki, Andrea Armani, Yanping Zhu, Pierre‐André Gilormini, Ana Marques, Ashutosh Dhingra, Desirée Böck, Matthew C. Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, , Adriano Aguzzi
The paper identifies transcription factors that regulate β-glucocerebrosidase activity, showing that USF2 and ONECUT2 have opposing effects on GCase levels and function.
bioRxiv · Apr 28, 2024 · PreprintMolecular Biology