Matthew C. Deen

A lysyl oxidase (LOX)/bone morphogenetic protein-1 (BMP1) complex to facilitate collagen remodeling

This study identifies a stable LOX/BMP1 protein complex that facilitates collagen remodeling by enhancing LOX association with collagen type I and promoting efficient targeting to nascent collagen fibrils.

LRRK2 Kinase Activity Regulates Parkinson's Disease-Relevant Lipids at the Lysosome

This study shows that LRRK2 kinase activity affects BMP and GSL levels in lysosomes, linking lysosomal dysfunction to Parkinson's disease through changes in GCase activity and BMP accumulation.

Direct and indirect regulation of β- glucocerebrosidase by the transcription factors USF2 and ONECUT2

The paper identifies transcription factors that regulate β-glucocerebrosidase activity, showing that USF2 and ONECUT2 have opposing effects on GCase levels and function.