Chiara Trevisan

The paper performs a genome-wide CRISPR activation screen to identify genes modulating PrPC abundance, finding 531 genes with significant effects and validating 45 of them.

This study uses quantitative 3D histochemistry to show that netoglitazone reduces amyloid-beta plaques in specific brain regions of a mouse AD model.

The paper identifies transcription factors that regulate β-glucocerebrosidase activity, showing that USF2 and ONECUT2 have opposing effects on GCase levels and function.

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.

This study uses longitudinal whole-brain imaging to show that anti-Aβ therapies have distinct spatial and temporal efficacies, with polythiophenes showing strong Aβ clearance.