Xi Chen

This paper introduces LUNAR, a self-supervised neural-physics learning framework for 3D localization microscopy that improves robustness to optical aberrations and high-density molecule localization.

This study identifies L-fucose as a monosaccharide neuromodulator that enhances synaptic function and mitigates Alzheimer's disease symptoms in mice.

This study shows that the filamentous fungus Thermothelomyces heterothallica C1 can produce thermostable SARS-CoV-2 spike protein with a human-like glycan profile, comparable to mammalian systems.

This study shows that sialic acid identity influences, but does not solely determine, host tropism of sialoglycan-binding streptococci by testing binding preferences of SLBRs to Neu5Ac and Neu5Gc.

This study characterizes the sialome of the human retina and identifies alterations in age-related macular degeneration (AMD) that may impact complement factor H binding.

The paper identifies transcription factors that regulate β-glucocerebrosidase activity, showing that USF2 and ONECUT2 have opposing effects on GCase levels and function.

The paper introduces a 9-digit code system for sialyltrisaccharides, revealing vast sialoglycan diversity and identifying a universal probe from AB5 toxin B subunits.

The paper develops sialoglycan-recognizing probes (SGRPs) to systematically study mammalian sialoglycome dynamics using established laboratory techniques.

This paper analyzes the genomic diversity and evolution of Escherichia albertii from Chinese and international isolates, revealing population structure, virulence gene distribution, and high multidrug resistance prevalence.

The paper studies how two antibodies recognize the glycan antigen CA19-9 using crystallography and computational methods to improve antibody affinity.

The paper shows bacterial AB5 toxin B subunits evolve rapidly and independently of A subunits, with sialic acid binding preferences linked to host range and toxicity.