TDP-43 regulates the expression levels of Disc-large in skeletal muscles to promote the assemble of the neuromuscular synapses in Drosophila
Nina Strah, Giulia Romano, Clelia Introna, Raffaella Klima, Aram Megighian, Monica Nizzardo, Fabian M. Feiguin
This study shows TDP-43 promotes neuromuscular synapse formation in Drosophila by regulating Disc-large expression, with similar mechanisms observed in human ALS tissues.
bioRxiv · Jul 26, 2019 · PreprintNeuroscience