Leptin alleviates obesity hypoventilation via serotonergic pathways
Dashdulam Davaanyam, Melanie Alexis Ruiz, Júnia L. de Deus, Mi Kyung Shin, Cole Winston, Xin Wang, Mateus R. Amorim, David Mendelowitz, Vsevolod Y. Polotsky
This study shows leptin alleviates obesity hypoventilation by activating serotonergic neurons in the medullary raphe that innervate hypoglossal motoneurons.
bioRxiv · Jun 29, 2026 · PreprintPhysiology