USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells
Paul C.M. van den Berk, Cesare Lancini, Michela Serresi, María Pilar Sánchez-Bailón, Danielle Hulsman, Colin Pritchard, Ji‐Ying Song, Matthias Jürgen Schmitt, Ellen Tanger, Oliver Popp, Philipp Mertins, Ivo Johan Huijbers, Heinz Jacobs, Maarten van Lohuizen, Gaetano Gargiulo, Elisabetta Citterio
This study identifies USP15 as critical for hematopoietic stem cell maintenance and genome integrity, showing its depletion impairs expansion and increases genotoxic stress in leukemia cells.
Cell Reports · Dec 1, 2020Peer-reviewedGenetics