Philipp Mertins

Multi-omics Insight into Cardiac Myofibril Remodeling in Post-Prandial Burmese Pythons

This study investigates cardiac myofibril remodeling in Burmese pythons during digestion using multi-omics approaches, revealing post-translational modifications as key to increased contractility.

Neuroblastoma-derived small extracellular vesicles retaincellular identity and adrenergic/mesenchymal state signatures

This study shows that neuroblastoma-derived sEVs retain genomic subgroup and lineage state signatures from their parental cells.

Translating multi-omics complexity into sparse prognostic biomarkers for multiple myeloma

This paper identifies prognostic biomarkers for multiple myeloma by integrating multi-omics data and shows that proteomic features outperform genomic or transcriptomic data in classification.

Myeloid cell recruitment propels right ventricular dysfunction in HFpEF via sterile inflammation.

This paper shows that myeloid cell recruitment drives right ventricular dysfunction in HFpEF through sterile inflammation in both mice and humans.

Quantitative profiling of JMJD6-catalysed lysine hydroxylation reveals a graded, residue-dependent readout of oxygen availability

This study quantitatively profiles JMJD6-catalyzed lysine hydroxylation, revealing a graded, residue-dependent response to oxygen availability in lysine-rich regions.

Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics.

This study identifies SVIL haploinsufficiency as a cause of hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics, with potential therapeutic implications for mitochondrial-targeted treatments.

TMPRSS2 regulates ACE2 trafficking and shedding

This study investigates how TMPRSS2 affects ACE2 trafficking and shedding, showing that TMPRSS2 interaction alters ACE2 processing and glycosylation impacts these effects in vivo.

Endothelial YAP/TAZ rewiring under cardiometabolic stress drives sex-divergent vascular remodeling in heart failure with preserved ejection fraction

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.

Autophagy selectively clears ER in inflammation-induced muscle atrophy

This study reveals that autophagy selectively clears the endoplasmic reticulum during inflammation-induced muscle atrophy, challenging the classical view of atrophy as a uniform degradation process.

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space

This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.

Distinct roles for MNK1 and MNK2 in social and cognitive behavior through kinase-specific regulation of the synaptic proteome and phosphoproteome

This study shows that MNK1 and MNK2 have distinct roles in social and cognitive behaviors by regulating different aspects of the synaptic proteome and phosphoproteome in knockout mice.

Multi-omics analysis reveals vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction in hazelnut allergy

This study identifies molecular differences in hazelnut allergy using multi-omics analysis, finding IL-5 as a key biomarker and linking the condition to vitamin D metabolism, hyper-IgE genes, and epithelial barrier dysfunction.

Butyrate Rescues Cardiac Metabolic Dysfunction in Hypertensive Heart Failure with Preserved Ejection Fraction

This study shows that butyrate improves diastolic function and reduces fibrosis in hypertensive HFpEF rats by serving as an alternative energy source.

Autophagy acts as a brake on obesity-related fibrosis by controlling purine nucleoside signalling

This study shows that autophagy in adipocytes limits obesity-related fibrosis by controlling purine nucleoside metabolism and macrophage polarization.

Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated transcriptome in human cells

This study rapidly depletes UPF1 in human cells to investigate NMD-regulated transcriptome dynamics, identifying core transcripts and biological processes affected.

Integrated Multi-omic Profiling Reveals Early Regulatory Events in Dexamethasone Muscle Atrophy

The paper uses multi-omic profiling to study early regulatory changes in dexamethasone-induced muscle atrophy in C2C12 cells, identifying mitochondrial gene expression and alternative splicing alterations.

Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells

The paper introduces SPIED-DIA, a phosphoproteomics method, to identify synergistic signaling responses in colon cancer cells to MEK inhibition and growth factor stimulation.

BIRC5 dependency defines a targetable vulnerability in TP53 mutant acute myeloid leukemia

This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.

UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

Structural Determinants of Mucins in Influenza Virus Inhibition: The Synergistic Role of Sialylated Glycans and Molecular Size

This study examines how sialylated glycans and molecular size of bovine submaxillary mucins affect influenza virus inhibition.

LINC01503-MP is a Mitochondrial Microprotein That Promotes Cell Proliferation and Oxidative Metabolism.

This study identifies LINC01503-MP, a mitochondrial microprotein derived from an lncRNA, which promotes cell proliferation and oxidative metabolism in colorectal cancer cells.

Formation of amyloid-like HTTex1 aggregates in neurons, downregulation of synaptic proteins and early mortality of Huntington's disease flies are causally linked

This study links mHTTex1 aggregation in neurons to synaptic dysfunction and early mortality in HD flies through machine learning analysis and RNAi knockdown experiments.

Systemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the blood proteome

This study uses proteomics to compare the systemic effects of two CFTR modulator therapies in CF patients, finding that ELX/TEZ/IVA leads to proteome changes closer to healthy profiles.

TENM4 is an essential transduction component for touch

This study identifies TENM4 as an essential extracellular linker protein for mechanotransduction in mechanoreceptors, showing its role in touch sensitivity.

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification

This paper introduces DIA-SiS, a method combining DIA with spike-in SILAC to improve proteome coverage and quantification, showing better performance than label-free approaches.

Mechanical Strain Activates Planar Cell Polarity Signaling to Coordinate Vascular Cell Dynamics

This study identifies Vangl1 as a key mediator of flow-dependent cell dynamics in vascular remodeling through planar cell polarity signaling.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific interactors.

The paper identifies branch- and length-specific ubiquitin chain interactors in humans and yeast, revealing how different Ub architectures are decoded by proteins.

Proteomic Insights into Circadian Transcription Regulation: Novel E-box Interactors Revealed by Proximity Labeling

The paper identifies novel E-box interactors using proximity labeling proteomics in mouse fibroblasts, revealing proteins involved in circadian transcription regulation.

Quantitative modelling of signaling in aggressive B cell lymphoma unveils conserved core network

The paper models BCR signaling in B cell lymphoma cells to identify conserved network structures and crosstalk mechanisms.

Phosphorylation of PLPPR3 membrane proteins as signaling integrator at neuronal synapses

The paper identifies phosphorylation sites in PLPPR3 and shows that phosphorylation at S351 regulates its interaction with BASP1, suggesting a role for the PLPPR3-BASP1 complex in synaptic signaling.