Author

Paul C.M. van den Berk

The Netherlands Cancer InstituteORCID 0000-0003-1213-253XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Heinz JacobsiD· 2 shared Aldo SpanjaardiD· 1 shared Bas PilzeckeriD· 1 shared Ben MorrisiD· 1 shared Cesare LanciniiD· 1 shared Colin Pritchard· 1 shared Cor LieftinkiD· 1 shared Daniël de Groot· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Heinz JacobsORCID

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2 papers

Recent·Most cited

Molecular BiologyGenome biologyPeer-reviewedDec 31, 2024

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

Daniël de Groot, Aldo Spanjaard, Ronak Shah…·Heinz Jacobs

The paper investigates the molecular and genomic effects of a global DNA damage tolerance defect, identifying type 3 deletions as a mutational signature of replication stress.

1 citation

mousewhole-genome sequencing

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GeneticsCell ReportsPeer-reviewedDec 1, 2020

USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells

Paul C.M. van den Berk, Cesare Lancini, Michela Serresi…·Elisabetta Citterio

This study identifies USP15 as critical for hematopoietic stem cell maintenance and genome integrity, showing its depletion impairs expansion and increases genotoxic stress in leukemia cells.

25 citations

mouseexperimental assay

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