Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function
Matthew H. Brisendine, Dijanira Q. Nieves-Esparcia, Orion S Willoughby, John R. Brown, Daniel S. Braxton, Shelby N. Henry, Collin McCoin, John P. Thyfault, Jill K. Morris, Steven Poelzing, Robert W. Grange, Charles P. Najt, Joshua C. Drake
This study shows that exercise or donepezil treatment can reduce proteomic changes in sciatic nerves of 5xFAD mice, preserving neuromuscular function before cognitive decline.
bioRxiv · Jul 1, 2025 · PreprintNeuroscience