Author

Orion S Willoughby

Virginia TechORCID 0000-0002-0865-360XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Charles P. NajtiD· 2 shared Daniel S. Braxton· 2 shared John R. Brown· 2 shared Joshua C. DrakeiD· 2 shared Matthew H. BrisendineiD· 2 shared Shelby N. Henry· 2 shared Adele K. AddingtoniD· 1 shared Alexey V. ZaitseviD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Charles P. NajtORCID

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2 papers

Recent·Most cited

Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

Orion S Willoughby, Anna S. Nichenko, Matthew H. Brisendine, Niloufar Amiri, Shelby N. Henry, Daniel S. Braxton, John R. Brown, Braeden J. Kraft, Kalyn S. Jenkins, Adele K. Addington, Alexey V. Zaitsev, Steven T. Burrows, Ryan P. McMillan, Haiyan Zhang, Spencer A. Tye, , Joshua C. Drake

This study shows that Ulk1(S555) phosphorylation regulates metabolic flexibility by prioritizing amino acid metabolism during nutrient stress.

Molecular Metabolism · Nov 25, 2025Peer-reviewedPhysiology

Age-dependent remodeling of the sciatic proteome in 5xFAD mice can be attenuated by exercise or donepezil treatment to maintain neuromuscular function

Matthew H. Brisendine, Dijanira Q. Nieves-Esparcia, Orion S Willoughby, John R. Brown, Daniel S. Braxton, Shelby N. Henry, Collin McCoin, John P. Thyfault, Jill K. Morris, Steven Poelzing, Robert W. Grange, Charles P. Najt, Joshua C. Drake

This study shows that exercise or donepezil treatment can reduce proteomic changes in sciatic nerves of 5xFAD mice, preserving neuromuscular function before cognitive decline.

bioRxiv · Jul 1, 2025 · PreprintNeuroscience