Jill K. Morris

In 4-month-old APOE targeted-replacement mice, APOE4 remodels the liver proteome sex-dependently; in isogenic iPSC-derived hepatocytes it impairs respiration and raises glycolysis and lipid droplets.

This study shows that exercise or donepezil treatment can reduce proteomic changes in sciatic nerves of 5xFAD mice, preserving neuromuscular function before cognitive decline.

This study identifies APOE4-dependent metabolic changes in brain cells, showing increased glycolysis and mitochondrial dysfunction in neurons and astrocytes.

This study examines the acute cerebral blood flow response to moderate-intensity exercise in older adults, finding a rapid hippocampal-specific increase in blood flow in those with poor baseline perfusion.