The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide.
Usha Mahawar, Deanna L. Davis, Muthukumar Kannan, John Suemitsu, Christopher Oltorik, Faheem Farooq, Raheema Fulani, Collin Weintraub, Jeremy C. Allegood, Binks W. Wattenberg
This study investigates how different ORMDL isoforms regulate SPT activity and sphingolipid levels in response to ceramide, finding that each isoform has distinct sensitivity to ceramide.
bioRxiv · Mar 20, 2025Biochemistry