Author

Binks W. Wattenberg

Virginia Commonwealth UniversityORCID 0000-0002-7517-6567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Usha MahawariD· 3 shared Carmen Sato‐BigbeeiD· 2 shared Deanna L. DavisiD· 2 shared Faheem FarooqiD· 2 shared Jeremy C. AllegoodiD· 2 shared Raheema Fulani· 2 shared Babette FussiD· 1 shared Christopher OltorikiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

Usha MahawarORCID

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3 papers

Recent·Most cited

ORMDL3-mediated SPT regulation Coordinates Myelin Sphingolipid and Protein Synthesis in Oligodendrocytes

Usha Mahawar, Raheema Fulani, Karli Mockenhaupt, Sumit Saha, Faheem Farooq, Fatemah S. Afshari, Susmita Manam, Carmen Sato‐Bigbee, Babette Fuss, Jeffrey L. Dupree, Tomasz Kordula, Binks W. Wattenberg

This study shows that ORMDL3 regulates sphingolipid and protein synthesis in oligodendrocytes, affecting myelin structure and composition during development.

bioRxiv · Sep 24, 2026 · PreprintBiochemistry

The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide.

Usha Mahawar, Deanna L. Davis, Muthukumar Kannan, John Suemitsu, Christopher Oltorik, Faheem Farooq, Raheema Fulani, Collin Weintraub, Jeremy C. Allegood, Binks W. Wattenberg

This study investigates how different ORMDL isoforms regulate SPT activity and sphingolipid levels in response to ceramide, finding that each isoform has distinct sensitivity to ceramide.

bioRxiv · Mar 20, 2025Biochemistry

Dynamics of sphingolipids and the serine-palmitoyltransferase complex in oligodendrocytes during myelination.

Deanna L. Davis, Usha Mahawar, Victoria S. Pope, Jeremy C. Allegood, Carmen Sato‐Bigbee, Binks W. Wattenberg

The paper examines sphingolipid synthesis and the serine-palmitoyltransferase (SPT) complex in oligodendrocytes during myelination in postnatal rats, showing changes in SPT subunit levels and sphingolipid composition.

bioRxiv · Jan 15, 2020 · PreprintNeuroscience