Author

Usha Mahawar

Virginia Commonwealth UniversityORCID 0000-0002-7418-096XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Binks W. WattenbergiD· 3 shared Carmen Sato‐BigbeeiD· 2 shared Deanna L. DavisiD· 2 shared Faheem FarooqiD· 2 shared Jeremy C. AllegoodiD· 2 shared Raheema Fulani· 2 shared Amandeep GirdhariD· 1 shared Babette FussiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Binks W. WattenbergORCID

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 24, 2026

ORMDL3-mediated SPT regulation Coordinates Myelin Sphingolipid and Protein Synthesis in Oligodendrocytes

Usha Mahawar, Raheema Fulani, Karli Mockenhaupt…·Binks W. Wattenberg

This study shows that ORMDL3 regulates sphingolipid and protein synthesis in oligodendrocytes, affecting myelin structure and composition during development.

DOI 10.64898/2026.09.23.753788

mouseexperimental assay

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BiochemistrybioRxivMar 20, 2025

The individual isoforms of ORMDL, the regulatory subunit of serine palmitoyltransferase, have distinctive sensitivities to ceramide.

Usha Mahawar, Deanna L. Davis, Muthukumar Kannan…·Binks W. Wattenberg

This study investigates how different ORMDL isoforms regulate SPT activity and sphingolipid levels in response to ceramide, finding that each isoform has distinct sensitivity to ceramide.

5 citations

humanexperimental assay

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NeurosciencebioRxivPreprintJan 15, 2020

Dynamics of sphingolipids and the serine-palmitoyltransferase complex in oligodendrocytes during myelination.

Deanna L. Davis, Usha Mahawar, Victoria S. Pope…·Binks W. Wattenberg

The paper examines sphingolipid synthesis and the serine-palmitoyltransferase (SPT) complex in oligodendrocytes during myelination in postnatal rats, showing changes in SPT subunit levels and sphingolipid composition.

1 citation

ratexperimental assay

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BioinformaticsInternational Journal of Biological MacromoleculesPeer-reviewedJan 7, 2020

Computational insights into mechanism of AIM4-mediated inhibition of aggregation of TDP-43 protein implicated in ALS and evidence for in vitro inhibition of liquid-liquid phase separation (LLPS) of TDP-432C-A315T by AIM4.

Amandeep Girdhar, Vidhya Bharathi, Vikas Ramyagya Tiwari…·Basant Kumar Patel

This study uses computational methods to identify AIM4's binding site on TDP-43 and shows it inhibits LLPS of a TDP-43 mutant in vitro.

56 citations

protein structurestatistical model

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