Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation
Pancheng Xie, Xiaowen Xie, Congrong Ye, Kevin M. Dean, Isara Laothamatas, S. K. Tahajjul Taufique, Joseph S. Takahashi, Shin Yamazaki, Ying Xu, Yi Liu
The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.
Proceedings of the National Academy of Sciences · Dec 21, 2023Peer-reviewedGenetics