Kevin M. Dean

The paper maps gene-by-gene-by-environment epistasis in cancer metastasis using CRISPR perturbations in mice, showing niche-dependent fitness and transcriptome convergence.

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

This study identifies tumor-intrinsic IFNγ signaling and niche adaptation as key drivers of early colonization in ovarian cancer metastasis using MetTag, a single-cell barcoding approach.

This study maps how distinct oncogenic drivers induce unique multiscale architectural changes in liver tissue, revealing mutation-specific remodeling across cellular and mitochondrial structures.

This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.

Altair-dvOPM is an open-access microscope for large-field 3D tissue imaging, achieving micrometer resolution without custom objectives or specialized alignment.

This study shows that branched actin-driven membrane protrusions (BAMPs) enhance oncogenic KRAS signaling by amplifying upstream regulators and promoting cell proliferation through merlin inactivation.

Altair-LSFM is a high-resolution, open-source light-sheet microscope designed for sub-cellular imaging, achieving 235 nm lateral and 350 nm axial resolution.

This paper shows that bleb-induced septin signaling supports survival of metastatic melanoma cells in vivo, and disrupting this pathway reduces metastasis.

This paper introduces Cy-ExM, a high-plex imaging strategy that enables 3D super-resolution mapping of cellular ultrastructure in mammalian cells.

The paper introduces u-Segment3D, a tool that converts 2D cell segmentations into 3D consensus segmentations without training data, demonstrating effectiveness across diverse datasets.

The paper introduces miOPM, a reconfigurable LSFM platform that enables high-resolution imaging across multiple spatial scales and refractive indices.

The paper introduces MCT-ASLM, a microscopy platform that enables subcellular resolution imaging of whole tissues, demonstrating its application in studying neuronal circuits, kidney innervation, and tumor microenvironments.

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

The paper introduces a new image acquisition method for light-sheet microscopes that improves spatial context placement and reduces post-processing needs, achieving higher field of view and resolution.

This paper demonstrates adaptive optics in an oblique plane microscope, improving resolution and signal strength in zebrafish embryos.

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

The paper defines the anatomical structure of long-range and local proprioceptive circuits in mice, revealing distinct pathways and their functional implications.

The paper introduces a morphological motif detector for 3D microscopy images to analyze cell shape dynamics and signaling.

This paper shows that a Rac1 mutation drives melanoma proliferation independently of MAPK signaling by forming a mechanosensitive actin network that inactivates the tumor suppressor NF2/Merlin.