Ying Xu

Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

Single cell transcriptomics and developmental trajectories of murine cranial neural crest cell fate determination and cell cycle progression

This study uses single-cell RNA sequencing to reconstruct developmental trajectories of cranial neural crest cells in mice, identifying key fate determination events and cell cycle dynamics during facial development.

A resource of targeted mutant mouse lines for 5,061 genes

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

CNOT1 mediates phosphorylation via Protein kinase A on the circadian clock

This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.