The kinetics of bedaquiline diffusion in tuberculous cavities opens a window for emergence of resistance.
Annamarie E. Bustion, Jacqueline P. Ernest, Firat Kaya, Connie Silva, Jansy Passiflora Sarathy, Landry Blanc, Marjorie Z. Imperial, Martin Gengenbacher, Min Xie, Matthew D. Zimmerman, Gregory T. Robertson, Danielle Weiner, Laura E. Via, Clifton E. Barry, Radojka M. Savić, Veronique Anne Dartois
Rabbit lesion microdissection and pharmacokinetic modeling show bedaquiline takes months to reach deep caseum and years to clear, while TBAJ-587 and TBAJ-876 shorten these windows.
The Journal of Infectious Diseases · Jun 3, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest