Alpha-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinsons disease
Fanni F. Geibl, Martin T. Henrich, Zhong Xie, Enrico Zampese, Jun Ueda, Tatiana Tkatch, David L. Wokosin, Elena Nasiri, Constantin A. Grotmann, Valina Lynn Dawson, Ted M. Dawson, Navdeep S. Chandel, Wolfgang Hermann Oertel, Dalton James Surmeier
This study shows that alpha-synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons, leading to bioenergetic deficits and neuronal dysfunction in Parkinson's disease.
Molecular Neurodegeneration · Oct 8, 2024Peer-reviewedNeuroscience