Dalton James Surmeier

The paper maps dopamine subtype projections in the basal ganglia to reveal spatially distinct domains and their correlation with striatal neuron subclasses and cortical inputs.

Focal dopaminergic axon swellings in the dorsolateral striatum of Synj1 R259Q mutant mice are clusters of DAT-rich, onion-like plasma membrane invaginations, and the same region shows reduced evoked dopamine release.

The paper investigates how dopamine modulates tonic GABAergic signaling in the substantia nigra via astrocytic and dopaminergic neuron interactions.

This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.

This study identifies state-dependent modulation of spiny projection neurons in a mouse Parkinson's model and shows how disrupting specific signaling pathways reduces levodopa-induced dyskinesia.

This study shows that increasing mitochondrial NAD+ regeneration via MitoLbNOX does not rescue dopaminergic neuron dysfunction caused by complex I impairment in Parkinson's disease mice.

This study shows that intranasal administration of isradipine achieves higher brain concentrations than plasma, enabling targeted Cav1 Ca2+ channel inhibition with fewer peripheral side effects.

This study shows that alpha-synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons, leading to bioenergetic deficits and neuronal dysfunction in Parkinson's disease.

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

The paper studies sleep-wake abnormalities in a new PD mouse model and finds they mirror human PD symptoms, suggesting potential for understanding and treating sleep disruptions in PD.

The paper investigates how GABAergic inputs modulate striatal spiny projection neuron excitability, showing that GABAARs can depolarize neurons in the resting down-state, enhancing responses to glutamatergic inputs.

The paper investigates the role of Cav1.2 Ca2+ channels in pacemaking of PPN cholinergic neurons and their link to oxidative stress and Parkinson's disease vulnerability.

The paper identifies neuron-type-specific synaptic protein isoform expression in striatal spiny projection neurons and shows its impact on synapse diversity and dysfunction.

The paper shows that restoring autonomous subthalamic nucleus activity through chemogenetics reduces synaptic synchronization and improves motor symptoms in Parkinson's disease models.

This study shows that activating the dorsal hippocampus reduces neuropathic pain behaviors through specific neural circuits.