Zhong Xie

Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra

The paper investigates how dopamine modulates tonic GABAergic signaling in the substantia nigra via astrocytic and dopaminergic neuron interactions.

Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models

This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.

Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia

This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.

Alpha-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinsons disease

This study shows that alpha-synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons, leading to bioenergetic deficits and neuronal dysfunction in Parkinson's disease.

Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

EPAC2 is required for corticotropin-releasing hormone-mediated spine loss

This study shows that EPAC2 is required for CRH-induced dendritic spine loss in cortical neurons.