David L. Wokosin

State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease

This study identifies state-dependent modulation of spiny projection neurons in a mouse Parkinson's model and shows how disrupting specific signaling pathways reduces levodopa-induced dyskinesia.

Alpha-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinsons disease

This study shows that alpha-synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons, leading to bioenergetic deficits and neuronal dysfunction in Parkinson's disease.

Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

State-dependent GABAergic regulation of striatal spiny projection neuron excitability

The paper investigates how GABAergic inputs modulate striatal spiny projection neuron excitability, showing that GABAARs can depolarize neurons in the resting down-state, enhancing responses to glutamatergic inputs.

Dysregulation of the basal ganglia indirect pathway prior to cell loss in the Q175 mouse model of Huntington's disease

This study identifies early dysregulation in the basal ganglia indirect pathway in Q175 HD mice before cell loss, showing hypoactivity in striatal neurons and hyperactivity in GPe neurons.

Chemogenetic restoration of autonomous subthalamic nucleus activity ameliorates Parkinsonian motor dysfunction

The paper shows that restoring autonomous subthalamic nucleus activity through chemogenetics reduces synaptic synchronization and improves motor symptoms in Parkinson's disease models.

Nicotinic cholinergic receptors in VTA glutamate neurons modulate excitatory transmission

This study shows that VTA glutamate neurons express nicotinic acetylcholine receptors and are modulated by cholinergic input, affecting excitatory transmission.

Development of photoactivatable drugs enables nicotinic optopharmacology

This paper develops a method to create photoactivatable nicotine for optopharmacology studies of nicotinic acetylcholine receptors.