Tatiana Tkatch

The paper investigates how dopamine modulates tonic GABAergic signaling in the substantia nigra via astrocytic and dopaminergic neuron interactions.

This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.

This study identifies GluN2B-containing NMDAR up-regulation in iSPNs as a key mechanism in LID, showing that targeting these receptors can reduce dyskinesia without affecting levodopa's motor benefits.

This study identifies state-dependent modulation of spiny projection neurons in a mouse Parkinson's model and shows how disrupting specific signaling pathways reduces levodopa-induced dyskinesia.

This study shows that alpha-synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons, leading to bioenergetic deficits and neuronal dysfunction in Parkinson's disease.

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

The paper investigates how GABAergic inputs modulate striatal spiny projection neuron excitability, showing that GABAARs can depolarize neurons in the resting down-state, enhancing responses to glutamatergic inputs.

The paper investigates the role of Cav1.2 Ca2+ channels in pacemaking of PPN cholinergic neurons and their link to oxidative stress and Parkinson's disease vulnerability.