Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs
Joe McKellar, Jimmy M. Cadènes, Francisco García-de-Gracia, Corentin Aubé, Ana Luiza Chaves Valadão, Marine Tauziet, Mary Arnaud‐Arnould, Antoine Rebendenne, Lenka Kociánová, Emmanuel Labaronne, Emiliano P. Ricci, Bénédicte Delaval, Raphaël Gaudin, Nadia Naffakh, Sarah Gallois‐Montbrun, , Caroline Goujon
This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.
Proceedings of the National Academy of Sciences · Oct 7, 2025Peer-reviewedMicrobiology