Joe McKellar

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

Deltaviruses spread through a viral Trojan Horse

This study shows deltaviruses use helper virus particles as Trojan Horses for cell entry, revealing a new mode of viral transmission.

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs

This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.

SARS-CoV-2 predation of Golgi-bound PI4P primes the massive activation of the DNA Damage Response kinase ATM in the cytoplasm

This study shows SARS-CoV-2 hijacks Golgi-bound PI4P via OSBP1, leading to cytoplasmic ATM activation and impaired viral replication with ATM inhibitors.