Crystal structure of E. coli Nissle 1917 flagellin reveals novel features that modulate bacterial motility but not TLR5 recognition
Johanna Jakob, Michael B. Braun, Katharina Hipp, Iris Koch, Gaopeng Li, Pascal Felgner, María Giralt-Zúñiga, Hannah Raasch, Corinna Ghering-Khav, András Szolek, Abdelhakim Boudrioua, Thomas Hagemann, Samuel Wagner, Thilo Stehle, Liudmila Andreeva, , Alexander N.R. Weber
This study determines the crystal structure of E. coli Nissle 1917 flagellin and shows that hypervariable regions affect motility but not TLR5 recognition.
bioRxiv · Apr 14, 2026 · PreprintMicrobiology