Abdelhakim Boudrioua

The paper investigates how human-targeted drugs alter regulatory networks in Salmonella Typhimurium, revealing non-antibiotic compounds reshape virulence and antibiotic resistance through specific transcriptional responses.

This study determines the crystal structure of E. coli Nissle 1917 flagellin and shows that hypervariable regions affect motility but not TLR5 recognition.

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

This study shows that lasso peptides sviceucin and siamycin I reduce virulence and restore vancomycin effectiveness against resistant bacteria by targeting histidine kinases.