Samuel Wagner

The paper investigates how human-targeted drugs alter regulatory networks in Salmonella Typhimurium, revealing non-antibiotic compounds reshape virulence and antibiotic resistance through specific transcriptional responses.

The paper investigates the relationship between chaperone structure and substrate secretion order in bacterial type III secretion systems, finding that chaperone structure alone does not determine secretion hierarchy.

This study determines the crystal structure of E. coli Nissle 1917 flagellin and shows that hypervariable regions affect motility but not TLR5 recognition.

The paper identifies a synthetic small molecule, C26, that inhibits HilD, a key regulator of Salmonella secretion systems, thereby preventing bacterial invasion of host cells.

This study investigates the secretion mechanism of transmembrane effector proteins by Legionella T4bSS, revealing a two-step process involving an inner membrane intermediate.

The paper analyzes metagenomic time-series data to track the spread of antibiotic resistance genes through bacterial chromosomes, plasmids, and phages during antibiotic therapy.

This study reveals the structural control of type-3 secretion system assembly in Salmonella, showing how structural features guide the formation of a 24:16/15 basal body and regulate protein secretion.

The paper determines the structure of the T3SS export gate core using cryo-EM, revealing a helical assembly with 5:4:1 stoichiometry and identifying it as a key component of the secretion channel.