Human NLRC4 can act as a direct sensor for cytosolic flagellin
Gaopeng Li, Kenyatta Doumanas, Xiao Liu…·Alexander N.R. Weber
This study shows human NLRC4 can directly sense cytosolic flagellin without NAIP, while NAIP may inhibit this response.
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Universitätsklinikum TübingenORCID 0000-0003-3421-7438Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Gaopeng Li, Kenyatta Doumanas, Xiao Liu…·Alexander N.R. Weber
This study shows human NLRC4 can directly sense cytosolic flagellin without NAIP, while NAIP may inhibit this response.
Lisa S. Dopslaff, Maria Mateo Tortola, Varvara Varlamova…·Liudmila Andreeva
This study reports a novel mode of NLRP3 activation in zebrafish through cryo-EM structure analysis, revealing a distinct oligomeric arrangement and activation mechanism compared to humans.
Johanna Jakob, Michael B. Braun, Katharina Hipp…·Alexander N.R. Weber
This study determines the crystal structure of E. coli Nissle 1917 flagellin and shows that hypervariable regions affect motility but not TLR5 recognition.
Ana Tapia‐Abellán, L.-M. Funk, Tobias Schäfer…·Alexander N.R. Weber
This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.