Spontaneous replication fork collapse regulates telomere length homeostasis in wild type cells
Margherita Paschini, Abigail E. Gillespie, Cynthia M. Reyes, Corinne A. McCoy, Karen A. Lewis, Leslie W. Glustrom, Tatyana O. Sharpee, Deborah S. Wuttke, Victoria Lundblad
The paper shows that telomerase elongates a second substrate formed by spontaneous replication fork collapse in budding yeast, significantly contributing to telomere length homeostasis.
Proceedings of the National Academy of Sciences · Oct 26, 2026Peer-reviewedGenetics