Margherita Paschini

The paper shows that telomerase elongates a second substrate formed by spontaneous replication fork collapse in budding yeast, significantly contributing to telomere length homeostasis.

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

This paper presents a standardized pipeline to generate airway and alveolar organoids from human bronchoalveolar lavage fluid, enabling disease modeling with minimal starting material and simplified methods.

This study shows that airway injury triggers alveolar type 2 cell proliferation mediated by macrophages, revealing a myeloid-driven response in the lung.

This study identifies an injury-associated, plastic cell state in early-stage lung adenocarcinoma driven by the KRAS-ITGA3-SRC axis, showing its role in tumor initiation and progression.