NeuroscienceJournal of Cerebral Blood Flow & MetabolismPeer-reviewed
Spontaneous development of cerebrovascular pathology and microinfarcts in a mouse model of sickle cell disease.
Hyacinth I. Hyacinth, Courtney L Sugihara, Thomas Lee Spencer…·Andy Y. Shih
This study shows that aged SCD mice develop cerebral vasculopathy features seen in humans, with increased RBC velocity, occlusive events, and microinfarcts detected via in vivo two-photon imaging.