An Evolutionary Novelty in TRPV1 Functional Regulation: Characterization of a Dominant-Negative Isoform Exclusive to Catarrhine Primates
Sofía Cancino, Deny Cabezas-Bratesco, Ella Matamala, Julia M. York, Kattina Zavala, Cristian Montecinos, Sebastián Bustamante-Villarreal, R. Maldonado, Gonzalo Riadi, Sebastian E. Brauchi, Juan C. Opazo
The paper identifies a dominant-negative TRPV1 splice variant unique to catarrhine primates, which inhibits canonical TRPV1 function by preventing its membrane localization.
bioRxiv · Jan 24, 2025 · PreprintEvolutionary Biology