R. Maldonado

RNA-DNA triplex-forming miRNAs define an evolutionarily recent chromatin regulatory mechanism

The paper identifies RNA-DNA triplex-forming miRNAs in human cells and shows they are evolutionarily recent and associated with Ago2-chromatin interactions.

Evolutionary history and functional divergence of hydroxycarboxylic acid receptors in primates

This study investigates the evolutionary history and functional divergence of HCAR2 and HCAR3 in primates, finding multiple duplication events in apes and functional specialization of HCAR3.

An Evolutionary Novelty in TRPV1 Functional Regulation: Characterization of a Dominant-Negative Isoform Exclusive to Catarrhine Primates

The paper identifies a dominant-negative TRPV1 splice variant unique to catarrhine primates, which inhibits canonical TRPV1 function by preventing its membrane localization.

Characterizing higher order structures of chromatin in human cells

The paper investigates chromatin organization using MNase-seq and finds no evidence of differentially compacted domains, supporting an irregular model of large-scale chromatin structure.