Viral inhibition of the anaphase promoting complex enhances replication by elevating nucleotide pools
Owen J. Chen, Cynthia Y. Feng, Paola Blanchette, Reese Jalal Ladak, Maximilian Crosby, Mariana De Sa Tavares Russo, Yilin Wang, Cristina Fernandez, Yingke Liang, David M. Sharon, Mohamed Moustafa-Kamal, Isabelle Gamache, Nahum Sonenberg, Daina Zofija Avizonis, Jose G. Teodoro
This paper shows that viral inhibition of the APC/C enhances replication by increasing nucleotide pools through stabilization of biosynthesis enzymes.
PLoS Pathogens · Aug 12, 2026Peer-reviewedMicrobiology