Novel derivatives of BCV and (S)-HPMPA inhibit orthopoxviruses and human adenoviruses more potently than BCV
Yifan Zhang, Yanmin Wan, Cuiyuan Guo, Zhaoqin Zhu, Chao Qiu, Jiasheng Lu, Yanan Zhou, Jiaojiao Zheng, Fahui Dai, Xiaoyang Cheng, Kunlu Deng, Wanhai Wang, Youchun Wang, Wenhong Zhang
This study evaluates novel prodrugs based on (S)-HPMPA and (S)-HPMPC, finding that ODE-(S)-HPMPA formate is more potent against orthopoxviruses and adenoviruses than BCV, but less effective against HSV-1.
Signal Transduction and Targeted Therapy · Apr 10, 2025Peer-reviewedMicrobiology