Author

D. A. Golombek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. R. Damato· 1 shared C. H. Johnson· 1 shared C. Rakers· 1 shared D. Whitmore· 1 shared E. D. Herzog· 1 shared G. J. Patti· 1 shared G. van Ooijen· 1 shared H. Okamura· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. R. Damato

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Author profile →

2 papers

Recent·Most cited

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

M. F. Gonzalez-Aponte, A. R. Damato, L. L. Trebucq, T. Simon, S. P. Cardenas-Garcia, K. Cho, G. J. Patti, D. A. Golombek, J. J. Chiesa, E. D. Herzog

This study shows that TMZ efficacy in glioblastoma varies with time-of-day due to circadian rhythms in MGMT expression and promoter methylation, with optimal treatment at the peak of Bmal1 expression.

bioRxiv · Sep 13, 2023 · PreprintCancer Biology

The methyl cycle is a conserved regulator of biological clocks.

J.-M. Fustin, S. Ye, C. Rakers, M. Versteven, S. J. Cargill, K. T. Tamai, Y. Xu, M. L. Jabbur, R. Kojima, M. L. Lamberti, D. Whitmore, R. Stanewsky, R. Kageyama, T. Matsuo, K. Yoshioka-Kobayashi, , H. Okamura

This study shows the methyl cycle regulates circadian and somite segmentation clocks across species, highlighting its role as a conserved metabolic regulator of biological clocks.

bioRxiv · May 29, 2019 · PreprintEvolutionary Biology