Protein dynamics regulate distinct biochemical properties of cryptochromes in mammalian circadian rhythms
J. L. Fribourgh, A. Srivastava, C. R. Sandate, A. K. Michael, P. L. Hsu, C. Rakers, L. T. Nguyen, M. R. Torgrimson, G. C. G. Parico, S. Tripathi, N. Zheng, G. C. Lander, T. Hirota, F. Tama, C. L. Partch
The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.
bioRxiv · Aug 20, 2019 · PreprintBiochemistry