G. J. Patti

Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma

This study shows that TMZ efficacy in glioblastoma varies with time-of-day due to circadian rhythms in MGMT expression and promoter methylation, with optimal treatment at the peak of Bmal1 expression.

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and glycerol-mediated gluconeogenesis in mice

This study investigates how liver mitochondrial pyruvate carrier deficiency affects de novo lipogenesis and glycerol-mediated gluconeogenesis in mice, finding impaired DNL but no reduction in intrahepatic lipid and unchanged glucose levels despite reduced glycerol metabolism.

Adipocyte lipin 1 is positively associated with metabolic health in humans and regulates systemic metabolism in mice.

The paper shows that lower adipose lipin 1 in humans correlates with metabolic issues, and mice lacking adipocyte lipin 1 develop metabolic disorders.

Mitochondrial Pyruvate Carrier Inhibition Initiates Metabolic Crosstalk to Stimulate Branched Chain Amino Acid Catabolism

This study shows that inhibiting the mitochondrial pyruvate carrier reduces branched chain amino acid (BCAA) levels and phosphorylation of BCKDH by activating AMPK/mTOR signaling in patients with NASH and in vitro models.

Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids

This study shows that silencing ALT2 in diabetic liver reduces hyperglycemia by decreasing amino acid-derived gluconeogenesis.

Targeting fatty acid beta-oxidation impairs monocyte differentiation and prolongs heart allograft survival

This study shows that inhibiting fatty acid beta-oxidation impairs monocyte differentiation and improves heart allograft survival by reducing immune cell infiltration.

Sex Differences in Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities to Treatment

The paper identifies sex differences in glutamine metabolism in glioblastomas, showing male tumors have higher glutamine uptake and are more sensitive to GLS1 inhibition than female tumors.

NK cell metabolic adaptation to infection promotes survival and viral clearance.

This study shows HIF-1 is essential for NK cell survival and viral clearance during MCMV infection by regulating metabolism and preventing apoptosis.

Systems-Level Annotation of Metabolomics Data Reduces 25,000 Features to Fewer than 1,000 Unique Metabolites

The paper reduces 25,000 metabolomics features to fewer than 1,000 unique metabolites by removing degenerate and non-biological features in Escherichia coli samples.