Bacterial killing by complement requires direct anchoring of Membrane Attack Complex precursor C5b-7
D. J. Doorduijn, B. W. Bardoel, D. A. Heesterbeek, M. Ruyken, G. Benn, E. S. Parsons, B. Hoogenboom, S. H. Rooijakkers
This study shows that direct anchoring of C5b-7 is essential for MAC pore formation and bacterial killing, and bacteria can evade this by interfering with anchoring.
bioRxiv · Dec 17, 2019Immunology