Author

S. H. Rooijakkers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Organism:E. coli· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

J. A. van Strijp· 2 shared N. M. van Sorge· 2 shared P. C. Aerts· 2 shared A. C. Fluit· 1 shared A. Hendriks· 1 shared A. R. Horswill· 1 shared B. C. van der Wal· 1 shared B. Hoogenboom· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

J. A. van Strijp

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Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 14, 2023

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus

A. Hendriks, P. F. Kerkman, M. R. Varkila…·N. M. van Sorge

This study identifies WTA-specific IgM as a critical immune factor for human protection against S. aureus, outperforming IgG in opsonophagocytic activity and correlating with clinical outcomes.

DOI 10.1101/2023.07.14.548956

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 9, 2021

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections

L. de Vor, B. van Dijk, K. P. van Kessel…·S. H. Rooijakkers

The paper identifies human monoclonal antibodies that recognize Staphylococcus aureus biofilms in vitro and in vivo, with some specifically targeting biofilm-associated antigens.

DOI 10.1101/2021.02.09.429966

mouseproteomics

𝕏 PostBluesky

ImmunologybioRxivDec 17, 2019

Bacterial killing by complement requires direct anchoring of Membrane Attack Complex precursor C5b-7

D. J. Doorduijn, B. W. Bardoel, D. A. Heesterbeek…·S. H. Rooijakkers

This study shows that direct anchoring of C5b-7 is essential for MAC pore formation and bacterial killing, and bacteria can evade this by interfering with anchoring.

DOI 10.1371/journal.ppat.1008606

E. coliexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivFeb 28, 2018

Group IIA secreted phospholipase A2 in human serum kills commensal but not clinical Enterococcus faecium isolates

F. L. Paganelli, H. L. Leavis, S. He…·S. H. Rooijakkers

The paper shows human serum kills commensal Enterococcus faecium but not clinical isolates, mediated by hGIIA, highlighting a potential mechanism for hGIIA resistance in clinical strains.

DOI 10.1128/iai.00180-18

humanexperimental assay

𝕏 PostBluesky