Author

E. S. Parsons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Organism:human· 1

Frequent Co-Authors

B. Hoogenboom· 2 shared D. Bubeck· 2 shared A. Kundaje· 1 shared A. L. B. Pyne· 1 shared A. Menny· 1 shared A. P. Nievergelt· 1 shared A. R. Yon· 1 shared A. Rowley· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

B. Hoogenboom

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Disease diagnostics using machine learning of immune receptors

M. E. Zaslavsky, E. Craig, J. K. Michuda, N. Sehgal, N. Ram-Mohan, J.-Y. Lee, K. D. Nguyen, R. A. Hoh, T. D. Pham, K. Röltgen, B. Lam, E. S. Parsons, S. R. Macwana, W. DeJager, E. M. Drapeau, , S. D. Boyd

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

bioRxiv · Apr 26, 2022Immunology

Structural basis for tuning activity and membrane specificity of bacterial cytolysins

N. R. Shah, T. B. Voisin, E. S. Parsons, C. M. Boyd, B. Hoogenboom, D. Bubeck

This study investigates how bacterial cytolysins use cholesterol to selectively lyse cells by analyzing structural changes in intermedilysin bound to CD59.

bioRxiv · Jun 16, 2020Biochemistry

Bacterial killing by complement requires direct anchoring of Membrane Attack Complex precursor C5b-7

D. J. Doorduijn, B. W. Bardoel, D. A. Heesterbeek, M. Ruyken, G. Benn, E. S. Parsons, B. Hoogenboom, S. H. Rooijakkers

This study shows that direct anchoring of C5b-7 is essential for MAC pore formation and bacterial killing, and bacteria can evade this by interfering with anchoring.

bioRxiv · Dec 17, 2019Immunology

Single-molecule kinetics of pore assembly by the membrane attack complex

E. S. Parsons, G. J. Stanley, A. L. B. Pyne, A. W. Hodel, A. P. Nievergelt, A. Menny, A. R. Yon, A. Rowley, R. P. Richter, G. E. Fantner, D. Bubeck, B. W. Hoogenboom

This study uses AFM to analyze MAC assembly kinetics, finding that C9 incorporation is the rate-limiting step in pore formation.

bioRxiv · Nov 16, 2018Biophysics