Author

K. Karlsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:organoid / primary culture· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

C. Curtis· 3 shared A. Sockell· 2 shared C. J. Kuo· 2 shared K. Karagyozova· 2 shared Y.-H. Lo· 2 shared A. E. Gilchrist· 1 shared A. Khan· 1 shared A. Mah· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCancer Biology

C. Curtis

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Author profile →

3 papers

Recent·Most cited

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

A. Sockell, W. Wong, S. Longwell, T. Vu, K. Karlsson, D. A. Mokhtari, J. Schaepe, Y.-H. Lo, V. Cornelius, C. Kuo, D. A. Van Valen, C. Curtis, P. M. Fordyce

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

bioRxiv · Nov 1, 2022Bioengineering

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

B. L. LeSavage, A. E. Gilchrist, B. A. Krajina, K. Karlsson, A. R. Smith, K. Karagyozova, K. C. Klett, C. Curtis, C. J. Kuo, S. C. Heilshorn

This study shows that high stiffness engineered matrices induce chemoresistance in pancreatic cancer organoids through hyaluronan mechanosignaling and a plastic cancer stem cell phenotype.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology

Deterministic evolution and stringent selection during pre-neoplasia

K. Karlsson, M. J. Przybilla, E. Kotler, A. Khan, H. Xu, K. Karagyozova, A. Sockell, W. H. Wong, K. Liu, A. Mah, Y.-H. Lo, B. Lu, K. E. Houlahan, Z. Ma, C. J. Suarez, , C. Curtis

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

bioRxiv · Apr 9, 2022 · PreprintCancer Biology