Author

Y.-H. Lo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Sockell· 2 shared C. Curtis· 2 shared K. Karlsson· 2 shared A. Gracz· 1 shared A. Khan· 1 shared A. Mah· 1 shared B. Lu· 1 shared B. Zwarycz· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBioengineering

A. Sockell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A microwell platform for high-throughput longitudinal phenotyping and selective retrieval of organoids

A. Sockell, W. Wong, S. Longwell, T. Vu, K. Karlsson, D. A. Mokhtari, J. Schaepe, Y.-H. Lo, V. Cornelius, C. Kuo, D. A. Van Valen, C. Curtis, P. M. Fordyce

This paper introduces a microwell platform for high-throughput longitudinal phenotyping of organoids and their selective retrieval for molecular profiling, identifying genomic and expression changes linked to growth and polarity.

bioRxiv · Nov 1, 2022Bioengineering

Deterministic evolution and stringent selection during pre-neoplasia

K. Karlsson, M. J. Przybilla, E. Kotler, A. Khan, H. Xu, K. Karagyozova, A. Sockell, W. H. Wong, K. Liu, A. Mah, Y.-H. Lo, B. Lu, K. E. Houlahan, Z. Ma, C. J. Suarez, , C. Curtis

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

bioRxiv · Apr 9, 2022 · PreprintCancer Biology

Widespread sex ratio polymorphism in Caenorhabditis nematodes

Y. Huang, Y.-H. Lo, J.-C. Hsu, T. S. Le, F.-J. Yang, T. Chang, C. Braendle, J. Wang

The paper examines sex ratio polymorphism across 23 Caenorhabditis nematode species, finding that 12 species show strain-level variation, and challenges the sperm competition model as the sole explanation for biased sex ratios.

bioRxiv · Oct 26, 2021 · PreprintEvolutionary Biology

Growth Factor Independent 1 is a tumor suppressor gene in colorectal cancer

M.-S. Chen, Y.-H. Lo, X. Chen, C. Williams, J. Donnelly, Z. Criss, S. Patel, J. Butkus, N. Shroyer

This study shows GFI1 acts as a tumor suppressor in colorectal cancer by reducing its expression in advanced stages and inhibiting tumor growth in models.

bioRxiv · Jul 16, 2018Cancer Biology

Sox4 drives Atoh1-independent intestinal secretory differentiation toward tuft and enteroendocrine fates

A. Gracz, L. A. Samsa, M. J. Fordham, D. C. Trotier, B. Zwarycz, Y.-H. Lo, K. Bao, J. Starmer, N. F. Shroyer, R. L. Reinhardt, S. T. Magness

This study shows Sox4 drives intestinal secretory differentiation toward tuft and enteroendocrine fates independently of Atoh1.

bioRxiv · Apr 11, 2018Cell Biology