Pharmacology & ToxicologybioRxiv
Hijacking Methyl Reader proteins for Nuclear-Specific Protein Degradation
D. A. Nalawansha, K. Li, J. Hines, C. M. Crews
This paper designs and evaluates PROTACs that use L3MBTL3 to induce nuclear-specific degradation of FKBP12 and BRD2 by hijacking a methyl reader:E3 ligase complex.
DOI 10.1021/jacs.2c00874